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Cis-Regulatory Element Hijacking by Structural Variants Overshadows Topological Changes in Primary Prostate Cancer
Authors
James R. Hawley, Stanley Zhou, Christopher Arlidge, Giacomo Grillo, Ken Kron, Rupert Hugh-White, Theodorus van der Kwast, Michael Fraser, Paul C. Boutros, Robert G. Bristow, & Mathieu Lupien
Published
January 2021
PubMed bioRxiv DOI: 10.1101/2021.01.05.425333Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal
Authors
Rashim Pal Singh, Danny V. Jeyaraju, Veronique Voisin, Rose Hurren, Changjiang Xu, James R. Hawley, Samir H. Barghout, Dilshad H. Khan, Marcela Gronda, Xiaoming Wang, Yulia Jitkova, David Sharon, Sanduni Liyanagae, Neil MacLean, Ayesh K. Seneviratene, Sara Mirali, Adina Borenstein, Geethu E. Thomas, Joelle Soriano, Elias Orouji, Mark D. Minden, Andrea Arruda, Steven M. Chan, Gary D. Bader, Mathieu Lupien, & Aaron D. Schimmer
Published
May 2020
PubMed Cell Stem Cell DOI: 10.1016/j.stem.2020.04.010Noncoding mutations target cis -regulatory elements of the FOXA1 plexus in prostate cancer
Authors
Stanley Zhou, James R. Hawley, Fraser Soares, Giacomo Grillo, Mona Teng, Seyed Ali Madani Tonekaboni, Junjie Tony Hua, Ken J. Kron, Parisa Mazrooei, Musaddeque Ahmed, Christopher Arlidge, Hwa Young Yun, Julie Livingstone, Vincent Huang, Takafumi N. Yamaguchi, Shadrielle M. G. Espiritu, Yanyun Zhu, Tesa M. Severson, Alex Murison, Sarina Cameron, Wilbert Zwart, Theodorus van der Kwast, Trevor J. Pugh, Michael Fraser, Paul C. Boutros, Robert G. Bristow, Housheng Hansen He, & Mathieu Lupien
Published
January 2020
PubMed Nature Communications DOI: 10.1038/s41467-020-14318-9The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids
Authors
Ayesh K. Seneviratne, Mingjing Xu, Juan J. Aristizabal Henao, Val A. Fajardo, Zhenyue Hao, Veronique Voisin, G. Wei Xu, Rose Hurren, S. Kim, Neil MacLean, Xiaoming Wang, Marcela Gronda, Danny Jeyaraju, Yulia Jitkova, Troy Ketela, Michael Mullokandov, David Sharon, Geethu Thomas, Raphaël Chouinard-Watkins, James R. Hawley, Caitlin Schafer, Helen Loo Yau, Zaza Khuchua, Ahmed Aman, Rima Al-awar, Atan Gross, Steven M. Claypool, Richard Bazinet, Mathieu Lupien, Steven Chan, Daniel D. De Carvalho, Mark D. Minden, Gary D. Bader, Ken D. Stark, Paul LeBlanc, & Aaron D. Schimmer
Published
April 2019
PubMed Cell Stem Cell DOI: 10.1016/j.stem.2019.02.020Spatial genomic heterogeneity within localized, multifocal prostate cancer
Authors
Paul C. Boutros, Michael Fraser, Nicholas J. Harding, Richard Borja, Dominique Trudel, Emilie Lalonde, Alice Meng, Pablo H. Hennings-Yeomans, Andrew McPherson, Veronica Y. Sabelnykova, Amin Zia, Natalie S. Fox, Julie Livingstone, Yu-Jia Shiah, Jianxin Wang, Timothy A. Beck, Cherry L. Have, Taryne Chong, Michelle Sam, Jeremy Johns, Lee Timms, Nicholas Buchner, Ada Wong, John D. Watson, Trent T. Simmons, Christine P'ng, Gaetano Zafarana, Francis Nguyen, Xuemei Luo, Kenneth C. Chu, Stephenie D. Prokopec, Jenna Sykes, Alan Dal Pra, Alejandro Berlin, Andrew Brown, Michelle A. Chan-Seng-Yue, Fouad Yousif, Robert E. Denroche, Lauren C. Chong, Gregory M. Chen, Esther Jung, Clement Fung, Maud H. W. Starmans, Hanbo Chen, Shaylan K. Govind, James Hawley, Alister D'Costa, Melania Pintilie, Daryl Waggott, Faraz Hach, Philippe Lambin, Lakshmi B. Muthuswamy, Colin Cooper, Rosalind Eeles, David Neal, Bernard Tetu, Cenk Sahinalp, Lincoln D. Stein, Neil Fleshner, Sohrab P. Shah, Colin C. Collins, Thomas J. Hudson, John D. McPherson, Theodorus Kwast, & Robert G. Bristow
Published
May 2015
PubMed Nature Genetics DOI: 10.1038/ng.3315